个人简介
理学博士。1969年1月生。苏州大学特聘教授，苏州丝美特生物技术有限公司创始人兼首席科学家，美国tufts 大学生物医学系助理教授，苏州工业园区纳米领军人才、姑苏领军人才。现任职苏州大学纺织与服装工程学院及现代丝绸国家工程实验室，创建了苏州大学-tufts大学生物医用材料联合实验室。主要研究天然丝素蛋白生物材料的工业化制备及其在组织工程修复、药物递送、生物3d打印、生物传感器和日用品工业中的应用。正在主持国家自然科学基金中德科技合作项目、国家自然科学基金面上项目和工业横向项目。王晓沁于1991年获得山东大学微生物工程专业学士学位，1998年获得北京协和医科大学分子生物学硕士学位，2004年获得荷兰格罗宁根（groningen）大学博士学位。曾先后任职荷兰贝尔美德（biomade）生物技术公司、美国塔夫茨（tufts）大学生物医学系、美国etex生物技术公司、美国ekteino laboratory, cocoon biotech等生物技术公司，担任新产品和新技术研发负责人。
研究方向及主讲课程
主要研究方向：丝素蛋白基药物缓释及组织修复；功能化丝素蛋白生物材料
近五年主持的科研项目
1. 国家重点研发计划“生物医用材料研发及组织器官修复替代” （项目参与） 2017-2021
2. 国家自然科学基金中德合作项目：有效利用巨噬细胞可塑性促进骨再生 （项目主持） 2015年至今
3. 国家自然科学基金面上项目: 抗氧化剂修饰的丝素蛋白生物材料对细胞生长和功能的调控（项目主持）2012017年
4. 姑苏领军创业人才项目：丝素蛋白止血防粘连材料的开发和应用 （项目主持）2013-2017年
近五年发表的代表性论文和教材
2014-2017发表论文：
1. wu j, xie x, zheng z, li g, wang y, wang x*. effect of ph on polyethylene glycol (peg)-induced silk microsphere formation for drug delivery. materials science and engineering: c materials for biological applications. 2017 nov 1;80:549-557.
2. liu y, zheng z, guo s, li g, wang x*, kaplan dl. dna preservation in silk. biomaterials science. 2017 jun 27;5(7):1279-1292.
3. yang l, zheng z, qian c, wu j, liu y, guo s, li g, liu m, wang x, kaplan dl. curcumin-functionalized silk biomaterials for anti-aging utility. j colloid interface sci. 2017;496:66-77 (sci, if: 3.368)
4. luo t, yang l, wu j, zheng z, li g, wang x*, kaplan dl. stabilization of natural antioxidants by silk biomaterials. acs appl mater interfaces. 2016;8:13573-13582. doi: 10.1021/acsami.6b01636. epub 2016 may 17. pmid: 27139741 (sci, if: 7.145; field-weighted citation impact: 0.83; cited number: 2)
5. wu j, zheng z, li g, kaplan dl, wang x*. control of silk microsphere formation using polyethylene glycol (peg). acta biomaterialia. 2016;39:156-168. doi: 10.1016/j.actbio.2016.05.019. epub 2016 may 12. pmid: 27181879 (sci, if: 6.025; field-weighted citation impact: 1.98; cited number: 3)
6. zheng z, guo s, liu y, wu j, li g, liu m, wang x*, kaplan d. lithium-free processing of silk fibroin. j biomater appl. 2016;31:450-463. doi: 10.1177/0885328216653259. epub 2016 jun 12. pmid: 27298185 (sci, if: 2.764; field-weighted citation impact: 0; cited number: 0)
7. yu d，sun c, zheng z, wang x, chen d, wu h, wang x*, shi f. inner ear delivery of dexamethasone using injectable silk-polyethylene glycol (peg) hydrogel. int j pharm. 2016;503:229-237. doi: 10.1016/j.ijpharm.2016.02.048. epub 2016 mar 10. pmid: 26972377 (sci, if: 3.65; field-weighted citation impact: 5.03; cited number: 3)
8. li g, li f, zheng z, luo t, liu j, wu j, wang x*, kaplan dl. silk microfiber-reinforced silk composite scaffolds: fabrication, mechanical properties, and cytocompatibility. j mater sci. 2016;51:3025-3035 (sci, if: 2.302; field-weighted citation impact: 2.17; cited number: 2)
9. wang y, liang m, zheng z, shi l, su b, liu j, kaplan dl, zhang b, wang x*. adhesion prevention after laminectomy using silk-polyethylene glycol (peg) hydrogels. adv healthc mater. 2015;4:2120-2127 aug 24. doi: 10.1002/adhm.201500392. [epub ahead of print] pmid: 26386268 (sci, if: 5.76; field-weighted citation impact: 0.33; cited number: 1)
10. lu d, zheng z, guo s, wang c, kaplan dl, wang x*. binding quantum dots to silk biomaterials for optical sensing. j sensors. 2015:819373 (sci, if: 0.712; field-weighted citation impact: 0.45; cited number: 1)
11. zheng z, liu m, guo s, wu j, lu d, li g, liu s, wang x*, kaplan dl. incorporation of quantum dots in silk biomaterials for fluorescence imaging. j mater chem b mater biol med. 2015;3:6509-6519. pmid: 26257913 pmcid: pmc4527682 (sci, if: 4.872; field-weighted citation impact: …; cited number: 3)
12. li g, liu j, zheng z, wang x*, kaplan dl. structural mimetic silk fiber-reinforced composite scaffolds using multi-angle fibers. macromol biosci. 2015;15:1125-1133. doi: 10.1002/mabi.201400502. epub 2015 apr 16. pmid: 25879693 (sci, if: 3.85; field-weighted citation impact: 0.54; cited number: 2)
13. li g, li y, chen g, he j, han y, wang x*, kaplan dl. silk-based biomaterials in biomedical textiles and fiber-based implants. adv healthc mater. 2015;4:1134-1151 doi: 10.1002/adhm.201500002. epub 2015 mar 13. pmid: 25772248 pmcid: pmc4456268 (sci, if: 5.76; field-weighted citation impact: 1.3; cited number: 11)
14. lovett ml, wang x, yucel t, york l, keirstead m, haggerty l, kaplan dl. silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-vegf) therapeutics. eur j pharm biopharm. 2015;95:271-278 doi: 10.1016/j.ejpb.2014.12.029. epub 2015 jan 12. pmid: 25592326 (sci, if: 4.245; field-weighted citation impact: 3.07; cited number: 9)
15. wang x*, partlow b, liu jian, zheng z, su bo, wang y, kaplan d. injectable silk-polyethylene glycol hydrogels. acta biomaterialia. 2015;12:51-61 doi: 10.1016/j.actbio.2014.10.027. epub 2014 oct 25. pmid: 25449912 (sci, if: 6.025; field-weighted citation impact: 3.9; cited number: 15)
16. zhou shun, huang wenwen, belton david j, simmons leo o, perry carole c, wang x, kaplan dl. control of bioinspired silicification by genetically engineered fusion proteins: silk - silica binding peptides (sibps). acta biomaterialia. 2015;15:173-180 doi: 10.1016/j.actbio.2014.10.040. epub 2014 nov 4. pmid: 25462851 pmcid: pmc4331239 (sci, if: 6.025; field-weighted citation impact: 1.82; cited number: 7)
17. li c, luo t, zheng z, murphy ar, wang x*, kaplan dl. curcumin-functionalized silk materials for enhancing adipogenic differentiation of bone marrow-derived human mesenchymal stem cells. acta biomaterialia. 2015;11:222-232 doi: 10.1016/j.actbio.2014.08.009. epub 2014 aug 15. pmid: 25132274 pmcid: pmc4256115 (sci, if: 6.025; field-weighted citation impact: 2.08; cited number: 10)
18. yin y, huang p, li d, han z, wei g, zhou c, wen j, su b, wang y, wang x*. collagen nanofibers facilitated presynaptic maturation in differentiated neurons from spinal cord-derived neural stem cells through mapk/erk1/2- synapsin i signaling pathway. biomacromolecules. 2014;15:2449-2460 doi: 10.1021/bm500321h. epub 2014 jul 1. pmid: 24955924 (sci, if: 5.75; field-weighted citation impact: 1.18; cited number: 8)
19. leng x, liu b, su b, liang m, shi l, li s, qu s, fu x, liu y, yao m, wang y, wang x*, kaplan dl. in situ ultrasound imaging of silk hydrogel degradation and neovascularization. j tissue eng regen med. 2017;11:822-830; med. doi: 10.1002/term.1981. accession number: 25850825 doi: 10.1002/term.1981. epub 2015 apr 5. pmid: 25850825 (sci, if: 2.37; field-weighted citation impact: 0.74; cited number: 1)
20. qing liu, shufa zhou, zeyu zhao, zhaozhu zheng, gang li, xiaoqin wang. sf/polyethylene glycol nano-fibrous membranes loaded with curcumin, thermal science 2017, 21(4), 21-27. (sci, if 0.95)
授权发明专利情况
1 一种可注射丝素蛋白原位凝胶的制备方法及其应用 zl201310203722.2 发明 授权 2/3
2 一种大分子量丝素蛋白冻干粉的制备工艺 zl201410118465.7 发明 授权 1/2
3 一种家蚕丝素蛋白溶液制备及鉴定 201510071886.3 发明 实审 1/2
4 一种治疗内耳疾病的控释缓释丝素蛋白凝胶制剂 201520089733.1 发明 实审 1/2
5 一种用于药物控释的丝素-载药纳微米颗粒的制备方法 201510918623.1 发明 实审 1/4
6 一种大分子量丝素蛋白冻干粉、制备工艺及其应用 pct/cn2015/075019 发明 实审 1/7
7 一种用聚乙二醇制备丝素纳微米球的方法及其在药物控释中的应用 pct/cn2015/097464 发明 实审 1/3
8 一种三维复合结构肛瘘线及其制备方法 201510468318.7 发明 实审 5/5
9 一种具有纬纱张力控制器的的织机梭子 5834673 实用新型 授权 5/5
10 一种农药残留检测方法及检测试剂盒 201610538541.9 发明 实审 2/3
11 一种利用丝素蛋白对dna保存的方法及试剂盒 2016103882027 发明 实审 1/2
12 一种小口径圆纬机添纱装置 201610437082.5 发明 实审 5/5
13 一种制备医用管状支架的装置 201510612349.5 发明 实审 7/7
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